Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 48, Pages 13121-13125Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407169
Keywords
biological activity; laser chemistry; nanomaterials; nanotechnology
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Funding
- Grants-in-Aid for Scientific Research [25115701, 25670103, 25250001, 25702030] Funding Source: KAKEN
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A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
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