Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 51, Pages 14128-14131Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406786
Keywords
asymmetric catalysis; Michael addition; regioselectivity; supramolecular chemistry; synthetic methods
Categories
Funding
- NSFC [21372105, 21302075, 21032005, 21172097]
- International S&T Cooperation Program of China [2013DFR70580]
- 111 program from MOE of P.R. China
Ask authors/readers for more resources
The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to alpha,beta-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available