Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 6, Pages 1775-1779Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409342
Keywords
asymmetric synthesis; fluorine; imines; organocatalysis; phosphines
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Funding
- National Basic Research Program of China (973 Program) [2010CB833200]
- National Natural Science Foundation of China [21032006, 203900502, 20532040, 21290184]
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The combination of a new bifunctional phosphine and an acrylate generate a zwitterion insitu and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied to Mannich-type reactions to give excellent results and it demonstrates a broad substrate scope. Such reactivity is not accessible with general organophosphine catalytic modes. Preliminary investigations into the mechanism are also presented.
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