4.5 Article

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC

Journal

NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 14, Issue 2, Pages 169-171

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1193

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Funding

  1. NIAID NIH HHS [R01 AI050628-01, R01 AI064611, AI064611, AI50628, R01 AI050628] Funding Source: Medline

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'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-angstrom resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR V beta but with TCR V alpha.

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