Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 30, Pages 7789-7793Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403249
Keywords
cell adhesion; chirality; enantiomers; hydrogelators; nanofibers
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Funding
- National Science Foundation of China [51173105, 51273111]
- National Basic Research Program of China (973 Program) [2012CB933803]
- Program for Professors of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- SRF for ROCS and SEM
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In the three-dimensional (3D) extracellular matrix (ECM), the influence of nanofiber chirality on cell behavior is very important; the helical nanofibrous structure is closely related to the relevant biological events. Herein, we describe the use of the two enantiomers of a 1,4-benzenedicarboxamide phenylalanine derivative as supramolecular gelators to investigate the influence of the chirality of nanofibers on cell adhesion and proliferation in three dimensions. It was found that left-handed helical nanofibers can increase cell adhesion and proliferation, whereas right-handed nanofibers have the opposite effect. These effects are ascribed to the mediation of the stereospecific interaction between chiral nanofibers and fibronectin. The results stress the crucial role of the chirality of nanofibers on cell-adhesion and cell-proliferation behavior in 3D environments.
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