Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 80B, Issue 2, Pages 505-510Publisher
WILEY
DOI: 10.1002/jbm.b.30624
Keywords
reactive landing; sodium hyaluronan; haemocompatibility; surface immobilization; surface plasma treatment
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A novel dry process for immobilization of hyaluronan on stainless steel surfaces is presented. This process that we call reactive landing is based on an interaction of hyperthermal gas-phase hyaluronan ions with plasma-cleaned and activated stainless steel surfaces. Reactive landing is performed on a unique instrument that combines an in-situ plasma reactor with an electrospray ion source and ion transfer optics. Gas-phase hyaluronan anions are obtained by electrospray ionization of sodium hyaluronan solutions and immobilized by reactive landing on large-area stainless steel surfaces. The immobilized hyaluronan withstands extensive washing with polar solvents and solutions, and the washed surfaces maintain the protective properties against blood platelet activation. The mechanism of hyaluronan discharge and immobilization is discussed. (c) 2006 Wiley Periodicals, Inc.
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