Journal
CANCER BIOLOGY & THERAPY
Volume 6, Issue 2, Pages 178-184Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.6.2.3577
Keywords
ovarian cancer; curcumin; superoxide; cell cycle; apoptosis; Akt
Categories
Funding
- NCI NIH HHS [R01 CA102264, CA 102264] Funding Source: Medline
Ask authors/readers for more resources
Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the aim of the present study was to investigate the anticancer properties of curcumin in cisplatin - resistant human ovarian cancer cells in vitro. The results indicated that curcumin inhibited the proliferation of both cisplatin - resistant (CR) and sensitive (CS) human ovarian cancer cells almost equally. Enhanced superoxide generation was observed in both CR and CS cells treated with curcumin. Curcumin induced G(2)/M phase cell - cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase - 3 followed by PARP degradation. Curcumin also inhibited the phosphorylation of Akt while the phosphorylation of p38 MAPK was enhanced. In summary, our results showed that curcumin inhibits the proliferation of cisplatin - resistant ovarian cancer cells through the induction of superoxide generation, G(2)/M arrest, and apoptosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available