Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 47, Pages 12876-12879Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407689
Keywords
carbon dioxide; methylation; N-heterocyclic carbenes; organocatalysis; sustainable chemistry
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Funding
- Swiss Competence Centre in Energy and Mobility (CCEM) HyTech project
- CTI Swiss Competence Center of Energy Research (SCCER) on Heat and Electricity Storage
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N-methylation of amines is an important step in the synthesis of many pharmaceuticals and has been widely applied in the preparation of other key intermediates and chemicals. Therefore, the development of efficient methylation methods has attracted considerable attention. In this respect, carbon dioxide is an attractive C-1 building block because it is an abundant, renewable, and nontoxic carbon source. Consequently, we developed a highly chemoselective, metal-free catalytic system that operates under ambient conditions for the N-methylation of amines.
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