Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 31, Pages 8045-8049Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201311047
Keywords
actuators; drug delivery; hydrogels; polymers; soft robotics
Categories
Funding
- NSF [CBET-1066898]
- NIH [DP2-OD004346-01, R01 AR061460]
- Broad Medical Research Institute [IBD-0336]
- Northrop Grumman
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066898] Funding Source: National Science Foundation
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We report on a therapeutic approach using thermoresponsive multi-fingered drug eluting devices. These therapeutic grippers referred to as theragrippers are shaped using photolithographic patterning and are composed of rigid poly(propylene fumarate) segments and stimuli-responsive poly(N-isopropylacrylamide-co-acrylic acid) hinges. They close above 32 degrees C allowing them to spontaneously grip onto tissue when introduced from a cold state into the body. Due to porosity in the grippers, theragrippers could also be loaded with fluorescent dyes and commercial drugs such as mesalamine and doxorubicin, which eluted from the grippers for up to seven days with first order release kinetics. In an in vitro model, theragrippers enhanced delivery of doxorubicin as compared to a control patch. We also released theragrippers into a live pig and visualized release of dye in the stomach. The design of such tissue gripping drug delivery devices offers an effective strategy for sustained release of drugs with immediate applicability in the gastrointestinal tract.
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