Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 39, Pages 10476-10480Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201405779
Keywords
carbon dioxide; C-H activation; heterocycles; hydrogen; ruthenium
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Funding
- state of Mecklenburg-Vorpommern
- BMBF
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Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H-2 has been reported. Described herein is the combination of CO2 and H-2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H-2 system.
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