Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 2, Pages 149-160Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2105
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Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks). Phosphorylation of specific targets by cyclin-Cdk complexes sets in motion different processes that drive the cell cycle in a timely manner. In budding yeast, a single Cdk is activated by multiple cyclins. The ability of these cyclins to target specific proteins and to initiate different cell-cycle events might, in some cases, reflect the timing of the expression of the cyclins; in others, it might reflect intrinsic properties of the cyclins that render them better suited to target particular proteins.
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