Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 9, Pages 2422-2427Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201308666
Keywords
alkyl Grignard reagents; breast cancer; enantiospecificity; Kumada coupling; nickel
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Funding
- NIH NIGMS [R01GM100212]
- UC Cancer Research Coordinating Committee
- NCI [P30A062203, F31A177212]
- LaVerne Noyes Fellowship
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Alkyl Grignard reagents that contain beta-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.
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