Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 47, Pages 12912-12915Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402922
Keywords
aryl ethers; C-O bond cleavage; cross-coupling; methoxy functionalization; nickel
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Funding
- Kekule fellowship (Fonds der Chemischen Industrie)
- Studienstiftung des Deutschen Volkes
- DAAD
- China Scholarship Council
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The direct replacement of aromatic methoxy groups with activated carbon nucleophiles would give rise to novel synthetic pathways for targeted and diversity-oriented syntheses. We demonstrate here that this transformation can be achieved in a one-step reaction involving a bifunctional organolithium nucleophile in combination with a C-Ar-OMe bond-cleaving nickel catalyst. The resulting products are stable, alpha-CH active, and suitable for various further modifications.
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