Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 24, Pages 6249-6252Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402440
Keywords
biomarkers; lipids; mass spectrometry; oxidation; total synthesis
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Funding
- Universite de Montpellier I (BQR)
- CNRS
- Fondation pour la Recherche Medicale
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The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.
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