4.8 Article

Spontaneous Biomimetic Formation of (±)-Dictazole B under Irradiation with Artificial Sunlight

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 25, Pages 6419-6424

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403454

Keywords

alkaloids; aplysinopsin; biomimetic synthesis; natural products; self-assembly

Funding

  1. LabEx LERMIT

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Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for the first time. Experimental evidence for an easy access to challenging cyclobutane alkaloids of marine origin, which are often postulated to be biosynthetic precursors of more complex structures, is provided.

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