Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 5, Pages 1604-1607Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409467
Keywords
asymmetric catalysis; cycloaddition; heterocycles; palladium; synthetic methods
Categories
Funding
- Major Basic Research Development Program [2011CB833300]
- NNSF China [21372242, 21272251, 21032007]
- Chinese Academy of Sciences
- Croucher Foundation of Hong Kong
Ask authors/readers for more resources
A palladium-catalyzed asymmetric [3+2] cycloaddition reaction of vinylaziridines with alpha,beta-unsaturated ketones, wherein the alkenes have a single activator, is realized in high diastereo- and enantioselectivity, thus affording 3,4-disubstituted pyrrolidines in high yields with excellent ee values. The introduction of a methyl group at C1 of the vinyl group the vinylaziridines greatly improves the stereochemistry of the reaction. A plausible transition state is proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available