Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 15, Pages 3979-3982Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309914
Keywords
DNA crystal; nanostructure; self-assembly; tensegrity; triple-helix
Categories
Funding
- BBSRC [BB/H019219/1]
- NIGMS [GM-29554]
- NSF [CMMI-1120890, CCF-1117210, EFRI-1332411]
- ARO [MURI W911NF-11-10024]
- ONR [N000141110729, N000140911118]
- DOE [DE-SC0007991]
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1117210] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1120890] Funding Source: National Science Foundation
- Emerging Frontiers & Multidisciplinary Activities
- Directorate For Engineering [1332411] Funding Source: National Science Foundation
- Biotechnology and Biological Sciences Research Council [BB/H019219/1] Funding Source: researchfish
- BBSRC [BB/H019219/1] Funding Source: UKRI
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DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects.1 The design of these structures exploits Watson-Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies.2-4 The dimensions of these complexes can be increased by over five orders of magnitude through self-assembly of cohesive single-stranded segments (sticky ends).5,6 Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics,7 the direction of biological cascades,8 and the structure determination of periodically positioned molecules by X-ray diffraction.9 To this end we present a macroscopic 3D crystal based on the 3-fold rotationally symmetric tensegrity triangle3,6 that can be functionalized by a triplex-forming oligonucleotide on each of its helical edges.
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