Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 15, Pages 3913-3916Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400236
Keywords
asymmetric catalysis; carbenes; chiral proton shuttle; chiral -aminoketones; diazo compounds
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China [2012CB821600]
- 111 project of the Ministry of Education of China [B06005]
- Program for New Century Excellent Talents in University [NCET-10-0516]
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A highly enantioselective NH insertion reaction of -diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral -aminoketones, which are versatile building blocks in organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions.
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