Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 19, Pages 4812-4815Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402144
Keywords
antitumor agents; chemoembolization; drug delivery; iron oxide; liver cancer
Categories
Funding
- Innovation Technology Fund [ITS/066/09]
- RGC-General Research Fund [201213]
Ask authors/readers for more resources
A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an invivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available