Journal
CELL RESEARCH
Volume 17, Issue 2, Pages 89-99Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/sj.cr.7310143
Keywords
monoclonal antibody; cancer; gene therapy
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Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.
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