Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 96, Issue 2, Pages 330-340Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jps.20789
Keywords
terahertz pulsed imaging; far infrared; structural imaging; coating analysis; film coating; sugar coating; tablets; multilayer tablet; soft gelatin capsules; process analytical technology (PAT)
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Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered controlled release tablets, and soft gelatin capsules. It is possible to determine the spatial and statistical distribution of coating thickness in single and multiple coated products using 3D TPI. The measurements are nondestructive even for layers buried underneath other coating structures. The internal structure of coating materials can be analyzed. As the terahertz signal penetrates up to 3 mm into the dosage form interfaces between layers in multilayered tablets can be investigated. In soft gelatin capsules it is possible to measure the thickness of the gelatin layer and to characterize the seal between the gelatin layers for quality control. TPI is a unique approach for the nondestructive characterization and quality control of solid dosage forms. The measurements are fast and fully automated with the potential for much wider application of the technique in the process analytical technology scheme. (c) 2006 Wiley-Liss, Inc.
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