Journal
CURRENT ORGANIC SYNTHESIS
Volume 4, Issue 1, Pages 81-135Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017907779981552
Keywords
1,3-oxazolidin-2-one; cyclocarbamation reactions; 1,2-aminoalcohol; epoxides and aziridines; amino-acids; Curtius- rearrangement
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The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stercochemical outcome.
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