Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 4, Pages 1619-1631Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01580-06
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Funding
- NIAID NIH HHS [P30 AI060354] Funding Source: Medline
- NICHD NIH HHS [U01 HD040474, U01 HD040533, U01 HD40533] Funding Source: Medline
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The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T-cell responses restricted by two closely related HLA class I alleles, B*5701 and B*5703, that differ by two amino acids but are both associated with a dominant response to the same HIV-1 Gag epitope KF11 (KAFSPEVIP MF). When this epitope is presented by HLA-13*5701, it induces a TCR repertoire that is highly conserved among individuals, cross-recognizes viral epitope variants, and is rarely associated with mutational escape. In contrast, KF11 presented by HIA-B*5703 induces an entirely different, more heterogeneous TCR beta-chain repertoire that fails to recognize specific KF11 escape variants which frequently arise in clade C-infected HLA-B*5703(+) individuals. These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations.
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