Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 51, Pages 14055-14059Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407729
Keywords
cations; DNA structures; electrophoresis; G-quadruplexes; nanostructures
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Funding
- Natural Science and Engineering Research Council of Canada (NSERC) [RGPIN 105785-2012]
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Single-stranded DNAs and RNAs that are rich in the nucleobase guanine form four-stranded G-quadruplexes, which are held together by hydrogen-bonded guanine quartets. In aqueous solution, both DNA duplexes and G-quadruplexes are modest conductors of electrical charge. A tight, topologically constrained DNA construct called twDNA is now reported, in which a core of four guanine-rich single strands structurally and electronically links together four DNA double helices. The addition and removal of K+ or Sr2+ cations promote alternative conformers of twDNA, which have strikingly distinct electronic properties. Unlike DNA mechano-electronic switches that require large conformational changes, twDNA requires only modest twisting/untwisting structural attenuations to achieve electronic switching.
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