Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 128, Issue 2, Pages 222-226Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2006.11.026
Keywords
aging; longevity; Caenorhabditis elegans; Drosophila melanogaster; Anastrepha ludens; tocopherol; vitamin E
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Funding
- Intramural NIH HHS Funding Source: Medline
- NIA NIH HHS [P01 AG008761, P01 AG08761, P01 AG008761-170003, P01 AG022500] Funding Source: Medline
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Many compounds hold promise for pharmacologic manipulation of aging. However, such claims are difficult to investigate due to time and budget constraints. Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (Vitamin E) on longevity. gamma-Tocopherol represents the most abundant tocopherol in the Western diet, while alpha-tocopherol is selectively enriched in human plasma. Both isoforms demonstrate antioxidant activity and are proposed to have anti-aging activities. We compared the effects of alpha- and ytocopherol supplementation on lifespan in three invertebrate species. gamma-Tocopherol, but not alpha-tocopherol, slightly extended lifespan in nematodes, but neither significantly affected lifespan in two fly species. This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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