Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 50, Pages 13866-13870Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407642
Keywords
charge transfer; chiral recognition; hydrogen bonding; surface-enhanced Raman scattering
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Funding
- National Natural Science Foundation of China [21273091, 21221063, 21327803]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110061110017]
- 111 project [B06009]
- Development Program of the Science and Technology of Jilin Province [20110338, 20130305005GX]
- Grants-in-Aid for Scientific Research [13F03332] Funding Source: KAKEN
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Efficient and generic enantioselective discrimination of various chiral alcohols is achieved by using surface-enhanced Raman scattering (SERS) spectroscopy through charge-transfer (CT) contributions. The relative intensities of the peaks in the SERS spectra of a chiral selector are strongly dependent on the chirality of its surroundings. This highly distinct spectral discrepancy may be due to the tendency of chiral isomers to form intermolecular hydrogen-bonding complexes with the chiral selector in different molecular orientations, resulting in different CT states and SERS intensities of the adsorbates in the system. This study opens a new avenue leading to the development of novel enantiosensing strategies. A particular advantage of this approach is that it is label-free and does not employ any chiral reagents, including chiral light.
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