Journal
BIOLOGICAL PSYCHIATRY
Volume 61, Issue 3, Pages 367-373Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.04.007
Keywords
anorexia nervosa; association; gene; opioid; serotonin; susceptibility
Categories
Ask authors/readers for more resources
Background: A recent study reported strong evidence for the involvement of a region on human chromosome I and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for Ibis susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Methods: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. Results. We genotyped 4 SNPs in HTR1D) and 6 SNTs in OPRD1.3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D) and RAN. Conclusions: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available