Levels of vascular cell adhesion molecule-1 and endothelin-1 in ischemic stroke: A longitudinal prospective study

Objectives: To determine levels of vascular cellular adhesion molecule (VCAM)-1 and endothelin (ET)-1 in patients with stroke. Design and methods: Thirty-four patients were prospectively studied. Plasma levels of VCAM-1 and ET-1 were measured by ELISA within 72 h of the event, at 7 and 90 days. Results: Levels of VCAM-1 increased overtime, whereas ET-1 values were initially and persistently elevated. Conclusions: Increased circulating levels of VCAM-1 and ET -1 are present during stroke. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.