Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 29, Pages 7519-7523Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403450
Keywords
biosynthesis; fungi; maleic anhydride; tropolones
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Funding
- Al Baha University, Saudi Arabia (AAF)
- EPSRC [EP/F066104/1]
- Egyptian Mission Sector, Faculty of Pharmacy Cairo University
- Egyptian National Research Centre, Cairo, Egypt
- Biotechnology and Biological Sciences Research Council [BB/I003355/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K03927X/1, EP/F066104/1] Funding Source: researchfish
- BBSRC [BB/I003355/1] Funding Source: UKRI
- EPSRC [EP/K03927X/1, EP/F066104/1] Funding Source: UKRI
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A series of directed knockout experiments, combined with an in vitro assay of pathway components, has elucidated for the first time the chemical steps involved in the biosynthesis of the tropolone class of fungal maleic anhydrides. The pathway involves the stepwise oxidation of aldehyde and methyl carbon atoms to form a 1,2-dicarboxylate. A hydrolase-catalyzed interconversion of this and the corresponding maleic anhydride, followed by decarboxylation of the diacid leads to the pathway's final product of stipitatic acid.
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