Journal
DEVELOPMENT
Volume 134, Issue 3, Pages 439-448Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.02762
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Funding
- Medical Research Council [G0401440] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0401440] Funding Source: researchfish
- MRC [G0401440] Funding Source: UKRI
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The normal function of the nervous system requires that the constituent neurons are precisely 'wired together'. During embryogenesis, each neuron extends an axonal process, which can navigate a considerable distance to its target. Although a number of the receptors and guidance signals that direct axonal growth have been identified, less is known about the transcription factors that regulate the expression of these molecules within the neuron and its environment. This review examines recent studies in vertebrates and Drosophila that address the identity of the transcription factors that either control the repertoire of guidance receptors and signals that permits an axon to take a particular trajectory or act themselves as novel extracellular guidance factors.
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