Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 3, Pages 937-940Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201408677
Keywords
hierarchical structures; nanoparticles; protein engineering; self-assembly; supramolecular chemistry
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Funding
- ETH Zurich
- European Research Council under the European Union [ERC-AdG-2012-321295]
- Marie Curie Action within the FP7-PEOPLE program [IEF-2011-299400]
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Designing nanoscaled hierarchical structures with increasing levels of complexity is challenging. Here we show that electrostatic interactions between two complementarily supercharged protein nanocages can be effectively utilized to create nested Matryoshka-type structures. Cage-within-cage complexes containing spatially ordered iron oxide nanoparticles spontaneously self-assemble upon mixing positively supercharged ferritin compartments with AaLS-13, a larger shell-forming protein with a negatively supercharged lumen. Exploiting engineered Coulombic interactions and protein dynamics in this way opens up new avenues for creating hierarchically organized supramolecular assemblies for application as delivery vehicles, reaction chambers, and artificial organelles.
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