Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 55, Issue 2, Pages 304-307Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.304
Keywords
Cordyceps sp.; diphenyl ether; phenyl ether glycoside
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Two novel diphenyl ether glycosides and a new diphenyl ether, cordyol A-C (1-3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 mu g/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 mu g/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 mu g/ml.
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