Journal
TETRAHEDRON LETTERS
Volume 48, Issue 6, Pages 933-935Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.12.015
Keywords
organic-base; phthalide; regioselective; intramolecular cyclization
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The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules. (c) 2006 Elsevier Ltd. All rights reserved.
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