New, chiral phase transfer catalysts for effecting asymmetric conjugate additions of α-alkyl-α-cyanoacetates to acetylenic esters

A new, chiral phase transfer catalyst has been designed for the development of a general and useful procedure on the hitherto unknown, asymmetric conjugate additions of alpha-substituted-alpha-cyanoacetates to acetylenic esters with high enantioselectivity and moderate E/Z selectivity.