Journal
CANCER LETTERS
Volume 246, Issue 1-2, Pages 109-114Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.02.003
Keywords
esophageal carcinogenesis; benzo[a]pyrene; CYP1B1; methoxylated flavones
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Funding
- NIGMS NIH HHS [GM55561] Funding Source: Medline
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Esophageal cancer is common worldwide, with poor prognosis. Smoking, including exposure to polyaromatic hydrocarbons like benzo[a]pyrene (BaP), is a major risk factor. In human esophageal HET-1A cells, we found that time-dependent BaP-DNA binding was associated with upregulation of CYP1B1, but not CYP1A1, mRNA and protein. The dietary flavonoid 5,7-dimethoxyflavone significantly inhibited BaP-DNA binding and down-regulated BaP-induced CYP1B1 mRNA and protein. 3',4'-Dimethoxyflavone was an even more potent inhibitor of CYP1B1 expression, while resveratrol had no effect. Thus, dietary methoxylated flavones inhibited BaP-induced CYP1B1 transcription in a cell-specific manner and hold promise as chemopreventive agents in esophageal carcinogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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