Journal
CANCER LETTERS
Volume 246, Issue 1-2, Pages 92-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.02.001
Keywords
multiple myeloma; induced heteroduplex generator; NF-kappa B; I kappa B; polymorphisms
Categories
Ask authors/readers for more resources
Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, I kappa B alpha, binds to NF-kappa B preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases. This study investigates eight polymorphisms across the NFKBIA gene in large patient and control populations. Significant differences in the frequency of particular polymorphisms were noted between patients and controls. A risk haplotype [GCCTATCA] for MM was also identified (P= 0.006). Analysis of the genetics of NFKBIA may lead to associations with disease progression and survival and thus more personalized therapy. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available