Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 31, Pages 8113-8116Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402012
Keywords
enzymes; fluorescence; fluorescent probes; metalloenzymes; stereochemistry
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Funding
- Center for Innovation in Global Health (CIGH) at Stanford University School of Medicine
- Environmental Venture Project (EVP) grant from the Stanford Woods Institute for the Environment
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Reported herein is the design of fluorogenic probes specific for carbapenem-resistant Enterobacteriaceae (CRE) and they were designed based on stereochemically modified cephalosporin having a 6,7-trans configuration. Through experiments using recombinant beta-lactamase enzymes and live bacterial species, these probes demonstrate the potential for use in the specific detection of carbapenemases, including metallo-beta-lactamases in active bacterial pathogens.
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