Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 21, Pages 5366-5370Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402002
Keywords
core-shell structures; drug delivery; mesoporous materials; nanoparticles; photonic crystals
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Funding
- Key Basic Research Program (973 Project) [2013CB934104, 2012CB224805]
- NSFC [21101029, 21273041, 21210004, 21322311]
- State Key Laboratory of Pollution Control and Resource Reuse Foundation [PCRRF12001]
- Science & Technology Commission of Shanghai Municipality [08DZ2270500]
- Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials
- King Abdulaziz University (KAU) [32-3-1432/HiCi]
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Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200nm and dual-ordered mesopores of 3.1 and 5.8nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.
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