Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 9, Pages 2344-2348Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309885
Keywords
cancer; high-throughput screening; mesenchymal-mode migration; metastasis; microfluidics
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Funding
- Cancer Prevention and Research Institute of Texas [CPRIT-R1007]
- Emily Herman Research Fund
- Golfers Against Cancer Foundation
- [NIH-CA180083]
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Increasing evidence shows that activated mesenchymal migration is a key process of the metastatic cascade. Cancer cells usually gain such migratory capability through an epithelial-to-mesenchymal transition. Herein we present a high-throughput microfluidic device with 3120 microchambers to specifically monitor mesenchymal migration. Through imaging of the whole chip and statistical analysis, we can evaluate the two key factors of velocity and percentage related to cell migratory capacity at different cell densities in culture. We also used the device to screen antimetastatic drugs for their inhibition of mesenchymal migration and prevention of metastatic malignancy. This device will provide an excellent platform for biologists to gain a better understanding of cancer metastasis.
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