Journal
VACCINE
Volume 25, Issue 8, Pages 1464-1469Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.10.033
Keywords
adjuvant; cdiGMP; immune modulator; vaccine
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The identification of new adjuvants is a critical need in vaccinology. In this work, it is demonstrated that bis-(3',5')-cyclic dimeric guanosine monophosphate (cdiGMP) exhibits potent adjuvant properties. Subcutaneous co-administration of cdiGMP with P-galactosidase (P-Gal) to mice resulted in the elicitation of significantly higher antigen-specific serum IgG titres than in animals receiving P-Gal alone. Strong cellular immune responses, which were characterized by a balanced Th1/Th2 pattern, were also observed in response to the P-Gal protein and a peptide encompassing its MHC class I-restricted epitope in immunized animals. These results suggest that cdiGMP represents a promising adjuvant for vaccine development. (c) 2006 Elsevier Ltd. All rights reserved.
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