Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 5, Pages 1275-1278Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309072
Keywords
biosynthesis; carbohydrates; click chemistry; imaging agents; synthesis design
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Funding
- CNRS
- Societe d'Acceleration du Transfert de Technologies SATT Sud Est
- Region Provence-Alpes-Cote d'Azur
- Fondation pour la Recherche Medicale (FRM) [DCM20121225768]
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Legionella pneumophila is a pathogenic bacterium involved in regular outbreaks characterized by a relatively high fatality rate and an important societal impact. Frequent monitoring of the presence of this bacterium in environmental water samples is necessary to prevent these epidemic events, but the traditional culture-based detection and identification method requires up to 10 days. Reported herein is a method allowing identification of Legionella pneumophila by metabolic lipopolysaccharide labeling which targets, for the first time, a precursor to monosaccharides that are specifically present within the O-antigen of the bacterium. This new approach allows easy detection of living Legionella pneumophila, while other Legionella species are not labeled.
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