Journal
PHYSICAL REVIEW LETTERS
Volume 98, Issue 6, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.98.068103
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Funding
- NIGMS NIH HHS [R01 GM059849] Funding Source: Medline
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The mechanochemical kinetics of transcription elongation was examined with a combination of theoretical and experimental approaches. The predictive power of a sequence-dependent thermal ratchet model for transcription elongation was tested by establishing model parameters based solely on measurements under chemical perturbations and then directly predicting responses under mechanical perturbations without additional model parameters. Agreement between predicted and measured force-velocity curves provides strong support for a simple mechanochemical coupling mechanism.
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