Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 47, Pages 12827-12831Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409270
Keywords
antibiotics; antimicrobial peptides; dendrimers; Pseudomonas aeruginosa; peptides
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Funding
- University of Bern
- Swiss National Science Foundation
- European Marie Curie Initial Training Network BioChemLig
- Swiss TransMed
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Multidrug-resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug-resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third-generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug-resistant bacterial pathogens.
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