Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 24, Pages 6095-6100Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402341
Keywords
branched polymers; copolymerization; degradable polymers; transfection; vinyl oligomer
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Funding
- Health Research Board (HRB) of Ireland
- Science Foundation Ireland (SFI)
- SFI Principal Investigator Programme
- DEBRA Ireland
- DEBRA Austria
- National University of Ireland, Galway
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A series of degradable branched PDMAEMA copolymers were investigated with the linear PDMAEMA counterpart as gene-delivery vectors. The branched PDMAEMA copolymers were synthesized by controlled radical cross-linking copolymerization based on the vinyl oligomer combination approach. Efficient degradation properties were observed for all of the copolymers. The degree of branching was found to have a big impact on performance in transfection when tested on different cell types. The product with the highest degree of branching and highest degree of functionality had a superior transfection profile in terms of both transfection capability and the preservation of cell viability. These branched PDMAEMA copolymers show high potential for gene-delivery applications through a combination of the simplicity of their synthesis, their low toxicity, and their high performance.
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