Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 24, Pages 6070-6074Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402239
Keywords
natural products; NMR spectroscopy; NMR fingerprints; Parkinson's disease; total synthesis
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Funding
- Griffith University
- Australian Research Council [DP130102400, LE0668477, LE0237908]
- Australian Research Council [LE0668477] Funding Source: Australian Research Council
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The NMR spectrum of a mixture of small molecules is a fingerprint of all of its components. Herein, we present an NMR fingerprint method that takes advantage of the fact that fractions contain simplified NMR profiles, with minimal signal overlap, to allow the identification of unique spectral patterns. The approach is exemplified in the identification of a novel natural product, iotrochotazine A (1), sourced from an Australian marine sponge Iotrochota sp. Compound 1 was used as a chemical probe in a phenotypic assay panel based on human olfactory neurosphere-derived cells (hONS) from idiopathic Parkinson's disease patients. Compound 1 at 1 mm was not cytotoxic but specifically affected the morphology and cellular distribution of lysosomes and early endosomes.
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