Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 109, Issue 3, Pages 539-542Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2006.08.015
Keywords
Xylocarpus granatum; Meliaceae; antidiarrhoeal activity; intestinal transit
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The methanol extract of Xylocarpus granatum bark was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in mice. At the doses of 250 and 500 mg/kg per oral, the methanol extract showed significant and dose-dependent antidiarrhoeal activity in both models. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to atropine sulphate (5 mg/kg; i.m.). The results showed that the extracts of Xylocarpus granatum bark have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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