Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 18, Pages 4551-4555Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400900
Keywords
drug delivery; imaging; LRET; nanoparticles; sensing
Categories
Funding
- National Natural Science Foundation of China [51372260, 51132009, 21172043, 51072212, 51102259]
- Shanghai Rising-Star Program [12QH1402500]
- Nano special program of the Science and Technology Commission of Shanghai [11nm0505000]
- Development Foundation for Talents of Shanghai [2012035]
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Insufficient or excess drug doses, due to unknown actual drug concentrations at the focus, are one of the main causes of chemotherapy failure for cancers. In this regard, the real-time monitoring of the release of anticancer drugs from nanoparticle drug delivery systems is of crucial importance, but it remains a critical and unsolved challenge. Herein, we report the proposal and development of a novel concept of real-time monitoring of NIR-triggered drug release in vitro and in vivo by using simultaneous upconverted luminescence (UCL) and magnetic resonance (MR) imaging. Such a monitoring strategy features the high sensitivity of UCL and the high-resolution, noninvasiveness, and tissue-depth-independence of MR imaging. The dual-mode real-time and quantitative monitoring of drug release can be applied to determine online the drug concentrations in vivo in the tissue regions of interest and, therefore, to avoid insufficient or excess drug dosings.
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