Journal
PHYSIOLOGICAL GENOMICS
Volume 28, Issue 3, Pages 311-322Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00208.2006
Keywords
Alzheimer's disease; laser capture microdissection; Affymetrix microarrays; expression profiling; neuron; transcriptomics
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Funding
- NIA NIH HHS [P30 AG019610, P01 AG003991, 1-R01-AG-023193, P50 AG005681, K01 AG024079-01A2, P01 AG-03991, K01 AG024079-02, K01AG-024079, P50 AG005128, P30 AG-19610, R01 AG023193, AG-05128, K01 AG024079, U01AG016976, P50 AG-05681, U01 AG016976] Funding Source: Medline
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In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
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