Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 7, Pages 1746-1754Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201304060
Keywords
antimicrobial; bactericidal; nonfouling; polymers; zwitterions
Categories
Funding
- Defense Threat Reduction Agency [HDTRA1-10-1-0074]
- Office of Naval Research [N000141210441]
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Zwitterionic polymers are generally viewed as a new class of nonfouling materials. Unlike their poly(ethylene glycol) (PEG) counterparts, zwitterionic polymers have a broader chemical diversity and greater freedom for molecular design. In this Minireview, we highlight recent microbiological applications of zwitterionic polymers and their derivatives, with an emphasis on several unique molecular strategies to integrate antimicrobial and nonfouling properties. We will also discuss our insights into the bacterial nonfouling performance of zwitterionic polymers and one example of engineering zwitterionic polymer derivatives for antimicrobial wound-dressing applications.
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