Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 48, Issue 1, Pages 5-12Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.3234
Keywords
IL-8; epithelial-mesenchymal transition; autocrine; paracrine; signal pathways
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Funding
- National Basic Research Program of China (973 program) [2012CB9333004]
- National Natural Science Foundation of China [81272360, 81472473]
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The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT is a vital step of tumor progression and metastasis. Amid the increasing interest in tumor EMT, only a few studies focused on the soluble mediators secreted by tumor cells passing through this phenotypic switch. In this review, we focus on the essential role of interleukin-8 (IL-8) signaling for the acquisition and maintenance of tumor EMT via direct and indirect mechanisms. Besides the autocrine loop between IL-8 and tumor cells that have gone through EMT, IL-8 could potentiate adjacent epithelial tumor cells into a mesenchymal phenotype via a paracrine mode. Moreover, understanding the role of IL-8 in EMT will provide insight into the pathogenesis of tumor progression and may facilitate the development of an effective strategy for the prevention and treatment of metastatic cancer.
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